کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4314540 1290039 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neonatal ventral hippocampal lesions disrupt set-shifting ability in adult rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Neonatal ventral hippocampal lesions disrupt set-shifting ability in adult rats
چکیده انگلیسی

Set-shifting in a T-maze task was assessed in rats with a neonatal ventral hippocampal lesion (NVHL), a proposed animal model of schizophrenia. NVHL animals tested as adults were impaired in shifting to a new rule; an increase in perseverative errors suggested that this impairment stemmed from an inability to suppress the previously learned strategy. The NVHL animals’ performance is reminiscent of humans with prefrontal damage and patients with schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 205, Issue 1, 14 December 2009, Pages 294–298
نویسندگان
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