کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319222 | 1290804 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain](/preview/png/4319222.png)
The Balb/c mouse strain shows quantitative deficits of sociability and is behaviorally-hypersensitive to MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist. D-Serine (560 mg/kg, intraperitoneally), a full agonist for the obligatory glycine co-agonist binding site on the NMDA receptor, increased the amount of time Balb/c mice spend in a compartment containing the enclosed social stimulus mouse and the amount of time Balb/c mice spend exploring (sniffing) an inverted cup containing the enclosed social stimulus mouse in a standard sociability apparatus. These effects of D-serine on the impaired sociability of the Balb/c mouse strain were not due to a “nonspecific” effect on locomotor activity; importantly, the locomotor activity of the Balb/c mouse strain decreases in the presence of an enclosed or freely-moving social stimulus mouse. The data suggest that dimensions of the impaired sociability of the Balb/c mouse strain may be improved by targeted NMDA receptor agonist interventions.
Journal: Brain Research Bulletin - Volume 84, Issue 1, 15 January 2011, Pages 12–16