کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4320343 1290860 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dose–response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Dose–response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity
چکیده انگلیسی

The present dose–response study sought to determine the effects of subanesthetic dosages (4–16 mg/kg) of ketamine on locomotion, sensorimotor gating (PPI), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia. In addition, we examined whether ketamine-induced locomotion was influenced by the dark/light cycle. We found that ketamine increased locomotor activity in a dose dependent manner, but found no influence of the dark–light cycle. Additionally, ketamine dose-dependently interrupted PPI, resulting in prepulse facilitation at doses of 8 and 12 mg/kg. The dose of 12 mg/kg also induced impairments in working memory assessed by the discrete-trial delayed-alternation task. C-fos expression indicated that the dose-dependent behavioral effects of ketamine might be related to changes in the activity of limbic regions, notably hippocampus and amygdala.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 69, Issue 3, 14 April 2006, Pages 338–345
نویسندگان
, , , ,