کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323779 1613824 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A critical period for omega-3 nutritional supplementation in the development of the rodent visual system
ترجمه فارسی عنوان
یک دوره بحرانی برای مکمل های تغذیه ای امگا 3 در توسعه سیستم دیداری جوندگان
کلمات کلیدی
اسیدهای چرب ضروری، اسید داکوساگزائوئونیک، سیستم ویژوال، توسعه، پلاستیک رتینوکتال دوره بحرانی، تغذیه، گشت و گذار در چشم، نقشه های توپوگرافی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• The development of visual acuity depends on precise visual topographical maps.
• Omega-3 nutritional restriction alters the fine-tuning of visual topography.
• Omega-3 supplementation during early development restores visual topography.
• Omega-3 supplementation starting at later stages is no longer effective.
• We suggest a critical period for omega-3 intake during development.

Retinocollicular connections form precise topographical maps that are normally completed through the selective elimination of misplaced axons and the stabilization of topographically ordered axon terminals during early development. Omega-3 fatty acids, acquired exclusively through the diet, and its main metabolite, docosahexaenoic acid (DHA), are involved in brain development and synaptic maturation. We have previously shown that the nutritional restriction of omega-3/DHA results in abnormal retinocollicular topographical fine-tuning. Therefore, we studied the role of omega-3 fatty acids nutritional supplementation and the developmental time windows during which this postnatal supplementation would restore normal topographical maps in the visual system. Female rats and their litters were chronically fed with either control (soy oil) or restricted omega-3 (coconut oil) diets. Fish oil supplementation was introduced between either postnatal day (PND) 7-13, PND7-28 or PND21-42. At PND13, PND28 or PND42, animals received an anterograde eye injection of a neuronal tracer to visualize retinocollicular axons. Confirming previous observations we found that an omega-3/DHA deficiency resulted in an abnormally high innervation density of retinal axons at the visual layers of the superior colliculus (SC). Although a short-term fish oil supplementation between PND7-13 could not restore normal retinocollicular topography, an extended treatment between PND7-28 completely recovered normal innervation densities of retinotectal axons. However, a late onset supplementation protocol, between PND28-42, was no longer effective in the restoration of the abnormal topographical pattern induced by an early omega-3 nutritional malnutrition. The results suggest a critical period for omega3/DHA dietary intake for the proper development of visual topographical maps.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1615, 30 July 2015, Pages 106–115
نویسندگان
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