کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4324174 | 1613858 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats](/preview/png/4324174.png)
چکیده انگلیسی
In conclusion, the data demonstrate not only ongoing thalamic neuroinflammation but also marked neurodegeneration remote from the lesion site in the chronic phase after stroke in rats. Both, neuroinflammation and neurodegeneration were accessible to (immuno-) histochemical methods as well as to in vivo methods using [11C]PK11195-PET and T2â-weighted MRI. Although the functional roles of these dynamic processes remain to be elucidated, ongoing destruction of neuronal tissue is conceivable. Its inhibition using anti-inflammatory substances may be beneficial in chronic post-stroke conditions, while multimodal imaging can be used to evaluate putative therapeutic effects in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1581, 18 September 2014, Pages 80-88
Journal: Brain Research - Volume 1581, 18 September 2014, Pages 80-88
نویسندگان
Maureen Walberer, Sabine U. Jantzen, Heiko Backes, Maria A. Rueger, Meike H. Keuters, Bernd Neumaier, Mathias Hoehn, Gereon R. Fink, Rudolf Graf, Michael Schroeter,