Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model

► Microglia is transiently activated in the entire trigeminocervical complex in a rat facial cancer model. ► Astrocyte is lately activated following microglial hyperactivation, but persistently. ► The central glial hyperactivation suppresses early phase of allodynia/hyperalgesia in the model.