Effects of moderate and chronic exercise on the nitrergic system and behavioral parameters in rats

► We model an aerobic program along the entire life in rats. ► We study changes in the nitrergic system in cortex, hippocampus and striatum. ► We examine behavioral parameters in aged rats. ► Chronic exercise causes the upregulation of nitrergic system in cortex and striatum. ► Nitric oxide is involved in the benefit of exercise on learning, memory and anxiety.