Modulation of the cortical false belief network during development

The ability to represent false beliefs is commonly considered as to be the critical test for having a Theory of Mind (ToM). For correct predictions or explanations of other peoples' behavior it is necessary to understand that mental states are sometimes independent of reality and misrepresent the real state of the world. In contrast, when people hold true beliefs, predictions and explanations about behavior can simply be derived from reality. Previous neuroimaging studies with adults suggest that the dorsal medial prefrontal cortex (dmPFC) and the right temporo-parietal junction (rTPJ) are engaged in false belief reasoning. However, studies investigating the neural correlates of belief reasoning in children are rare. Using cartoon stories that depicted an unexpected transfer, we compared false belief reasoning with true belief reasoning in children of a narrow age range between 10 and 12 years and in adults. In both groups, the dorsal medial frontal cortex was activated during false versus true belief reasoning. In contrast to adults, children did not selectively recruit the rTPJ during false belief reasoning. We found a group by belief interaction in the right rostral PFC and the posterior cingulate cortex. In these areas, children compared to adults showed increased activity associated with false belief reasoning in contrast to true belief reasoning. These results implicate modulation of the cortical network that underlies false belief reasoning during development and far beyond the time children successfully master false belief tasks.

Research highlights
► Developmental changes of the cortical false belief network.
► Increased activity of the rostral prefrontal cortex in children compared to adults.
► A significant negative correlation between hippocampal NAA concentration and hippocampal volume was observed in patients with schizophrenia.
► Activation of the temporo-parietal junction during false belief reasoning only in adults.