کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4327967 | 1614150 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
rPer1 and rPer2 induction during phases of the circadian cycle critical for light resetting of the circadian clock
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: rPer1 and rPer2 induction during phases of the circadian cycle critical for light resetting of the circadian clock rPer1 and rPer2 induction during phases of the circadian cycle critical for light resetting of the circadian clock](/preview/png/4327967.png)
چکیده انگلیسی
Photic resetting of a biological clock is one of the fundamental characteristics of circadian systems and allows living organisms to adjust to a particular environment. Nocturnal light induces the Per1 and Per2 genes, which leads to a resetting of the circadian clock in the suprachiasmatic nucleus (SCN), the mammalian circadian center. In our present study, we investigated whether light differentially induces the rat Per1 (rPer1) and Per2 (rPer2) genes to enable resetting of their circadian clocks. In a 24-hour LD cycle (12Â h light:12Â h dark), which is shorter than the normal free-running period for rats, Per1 alone showed strong induction in the ventrolateral region of the SCN (VLSCN) during the early day. In contrast, in a 25Â hour LD cycle (12.5Â h light:12.5Â h dark), which is longer than the free running period for these animals, rPer2 alone was strongly induced in the VLSCN, at the end of the light phase and during the early dark periods. Our current findings therefore suggest that Per1 and Per2 are differentially regulated for daily entrainment to the LD cycle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1289, 15 September 2009, Pages 37-48
Journal: Brain Research - Volume 1289, 15 September 2009, Pages 37-48
نویسندگان
Mamoru Nagano, Akihito Adachi, Koh-hei Masumoto, Elizabeth Meyer-Bernstein, Yasufumi Shigeyoshi,