کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4329327 | 1614212 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in the expression and subcellular localization of RARα in the rat hippocampus during postnatal development
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کلمات کلیدی
CLSMRXRRARAMPARatRA - ATRAlong-term depression - افسردگی طولانی مدتlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Postnatal development - توسعه پس از زایمانCNS - دستگاه عصبی مرکزیRetinoic acid - رتینوئیک اسیدpostnatal day - روز پس از زایمانcentral nervous system - سیستم عصبی مرکزیdentate gyrus - شکنج دندانه دارLTD - محدودSubcellular localization - محلی سازی سلولRat - موش صحراییConfocal laser-scanning microscope - میکروسکوپ کانن کانال لیزر اسکنHippocampus - هیپوکامپ Retinoic acid receptor - گیرنده اسید رتینوئیکretinoic X receptor - گیرنده رتینوئیک Xretinoic acid receptors - گیرنده های اسید رتینوئیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Changes in the expression and subcellular localization of RARα in the rat hippocampus during postnatal development Changes in the expression and subcellular localization of RARα in the rat hippocampus during postnatal development](/preview/png/4329327.png)
چکیده انگلیسی
Retinoic acid receptors (RARs) are reported to mediate the effects of retinoid acid and participate in the maintenance of normal hippocampal function during embryonic and postnatal stages. RARα is the only one that has been reported to be continuously expressed among RARs in the CA1-CA3 areas of the hippocampus, at both the mRNA and the protein level. Here, we show the expression and subcellular localization of RARα in granule and pyramidal cells in various regions of the hippocampus during postnatal development of rats. We discovered that the expression level of RARα in postnatal hippocampal tissue gradually decreased over time with increasing developmental maturity of the nervous system. Moreover, the subcellular localization of RARα expression showed a phenomenon of intracellular translocation during the postnatal development period. This new discovery is inconsistent with a traditional viewpoint according to which RARα, as a nuclear transcription factor, is mainly expressed inside nucleus. This phenomenon suggests that RARα may have different actions during each stage of hippocampal development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1227, 28 August 2008, Pages 26-33
Journal: Brain Research - Volume 1227, 28 August 2008, Pages 26-33
نویسندگان
Hongmei Huang, Hua Wei, Xuan Zhang, Ke Chen, Yasha Li, Ping Qu, Xiaoping Zhang, Jie Chen, Youxue Liu, Li Yang, Tingyu Li,