کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4329578 1614221 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regional variability in age-related loss of neurons from the primary visual cortex and medial prefrontal cortex of male and female rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Regional variability in age-related loss of neurons from the primary visual cortex and medial prefrontal cortex of male and female rats
چکیده انگلیسی
During aging, changes in the structure of the cerebral cortex of the rat have been seen, but potential changes in neuron number remain largely unexplored. In the present study, stereological methods were used to examine neuron number in the medial prefrontal cortex and primary visual cortex of young adult (85-90 days of age) and aged (19-22 months old) male and female rats in order to investigate any age-related losses. Possible sex differences in aging were also examined since sexually dimorphic patterns of aging have been seen in other measures. An age-related loss of neurons (18-20%), which was mirrored in volume losses, was found to occur in the primary visual cortex in both sexes in all layers except IV. Males, but not females, also lost neurons (15%) from layer V/VI of the ventral medial prefrontal cortex and showed an overall decrease in volume of this region. In contrast, dorsal medial prefrontal cortex showed no age-related changes. The effects of aging clearly differ among regions of the rat brain and to some degree, between the sexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1218, 7 July 2008, Pages 1-12
نویسندگان
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