کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4331124 1614288 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for elevated nicotine-induced structural plasticity in nucleus accumbens of adolescent rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Evidence for elevated nicotine-induced structural plasticity in nucleus accumbens of adolescent rats
چکیده انگلیسی

Male Long–Evans rats were administered nicotine bitartrate or sodium tartrate either during adolescence (p29–43) or adulthood (p80–94). Route of administration was via subcutaneously implanted osmotic pump (initial dose 2.0 mg/kg/day, free base). Five weeks following nicotine administration, brains were processed for Golgi–Cox staining. Medium spiny neurons from nucleus accumbens (NAc) shell were digitally reconstructed for morphometric analysis. Total dendritic length and branch number were greater in medium spiny neurons from animals pretreated with nicotine during adolescence. A branch order analysis indicated that increased branch number was specific to higher order branches. Mean branch lengths did not differ with respect to treatment as a function of branch order. Thus, nicotine-induced increases in total dendritic length were a function of greater numbers of branches, not increased segment length. In contrast, adult nicotine exposure did not significantly alter total dendritic length or branch number of medium spiny neurons. Total dendritic length and branch number of a second morphological type, the large aspiny neuron, did not differ following either adolescent or adult pretreatment. The age-dependent alteration of accumbal structure was associated with qualitatively different behavioral responses to drug challenge. These data provide evidence that drug-induced structural plasticity in nucleus accumbens is considerably more pronounced during adolescence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1151, 2 June 2007, Pages 211–218
نویسندگان
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