کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331188 | 1614292 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus
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کلمات کلیدی
MCAICAECAACAi.p.MCAOHspAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPenzyme-linked immunosorbant assay - آنزیم ایمونوسیوربنت تست شدهmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیIschemia - ایسکمیELISA - تست الیزاIntraperitoneally - داخل صفاقیSMA - دبیرستانSelenium - سلنیومanterior cerebral artery - شریان مغزی قدامیmiddle cerebral artery - شریان مغزی میانیexternal carotid artery - شریان کاروتید خارجیinternal carotid artery - شریان کاروتید داخلیHeat shock protein - پروتئین شوک حرارتcaspase - کسپاز یا کاسپازCalcium - کلسیمIntracellular calcium - کلسیم داخل سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
During cerebral ischemic cascade, a unifying factor which leads to mitochondrial dysfunctions is lack of oxygen followed by decrease in ATP production. The present study demonstrates the effect of selenium pretreatment (0.1 mg/kg as sodium selenite, i.p, 7 days) on cerebral ischemia-induced altered levels of mitochondrial ATP content, intracellular calcium (Cai2+) in synaptosomes, expression of heat stress protein (Hsp70) and caspase-3 activity in hippocampus followed by neurobehavioral deficits and histopathological changes in Wistar rats. Cerebral ischemia was induced for 2 h followed by reperfusion for 22 h. It was observed that levels of (Cai2+), Hsp70 and caspase-3 activity were significantly (p < 0.01-0.001) higher with a marked decrease in ATP level in hippocampus of ischemic group as compared to sham values. Subsequently, a marked change was observed in neurobehavioral activities in ischemic animals as compared to control one. As a result of selenium pretreatment, a significant (p < 0.05-0.001) trend of restoration was observed in the level of ATP, (Cai2+), Hsp70, caspase-3 and behavioral outputs as compared to ischemic group. Histopathological analysis confirmed the protective effect of selenium against cerebral ischemia induced histological alterations as evidenced by lesser edema formation and separation of cells with minimal microglial cell infiltration in selenium pretreated group as compared to ischemic animals. The present study suggests that selenium may be able to salvage the ischemic penumbral zone neurons, thereby limiting ischemic cell death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1147, 25 May 2007, Pages 218-225
Journal: Brain Research - Volume 1147, 25 May 2007, Pages 218-225
نویسندگان
Seema Yousuf, Fahim Atif, Muzamil Ahmad, Md. Nasrul Hoda, M. Badruzzaman Khan, Tauheed Ishrat, Fakhrul Islam,