کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331360 | 1614294 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticonvulsant actions of deoxycorticosterone
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کلمات کلیدی
ED50ACTHtetrahydrodeoxycorticosteroneDeoxycorticosteroneFLEFLCMMTTHDOCADTafterdischargePTZfLFDOCelectroencephalograph - الکتروانسفالوگرافیafterdischarge threshold - بعد از تخلیه آستانهKindled seizure - تشنج تشخیص داده شده استMaximal electroshock seizure - تشنج حداکثر الکتریکیMin - حداقلminutes - دقایقCarbon dioxide - دیاکسید کربنMeS - مسEEG - نوار مغزیpentylenetetrazol - پنتیلن تترازولCO2 - کربن دیاکسیدCORT - کورتCorticosterone - کورتیکوسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Purpose: Adrenocorticotrophic hormone (ACTH) suppresses several types of childhood seizures, but it has many side effects. The mechanism of ACTH's anticonvulsant actions is not known. ACTH, however, releases deoxycorticosterone (DOC) - as well as cortisol - from the adrenal cortex and it has been suggested that DOC may mediate, at least in part, ACTH's anticonvulsant actions. The present study assessed DOC's anticonvulsant actions in infant rats. Age-related changes in DOC's anticonvulsant actions were also studied. Methods: DOC's anticonvulsant actions were assessed against hippocampal-kindled, maximal pentylenetetrazol test (MMT) and maximal electroshock (MES) seizures in 15-day-old rats. Age-related changes in responsiveness to DOC were also assessed using the MMT model. Results: DOC suppressed generalized convulsions in all three of the seizure models. Focal spiking in the hippocampal-kindling model, however, was not fully suppressed, even at high doses. Ataxia increased proportionally with the dose, with the time of peak seizure suppression roughly correlating with the time of peak ataxia in all models. DOC was anticonvulsant in both infant and adult rats. ED50s, however, were much higher in adults. Young rats showed ataxia at the time of testing (15Â min), whereas adult rats did not, although ataxia was seen at later times. Conclusions: DOC is a potent anticonvulsant against generalized seizures, particularly in infants. It deserves a clinical test against generalized seizures in infants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1145, 11 May 2007, Pages 81-89
Journal: Brain Research - Volume 1145, 11 May 2007, Pages 81-89
نویسندگان
Claudia Perez-Cruz, Deborah Lonsdale, W. McIntyre Burnham,