کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331836 | 1292878 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke
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کلمات کلیدی
MCAOCCAsSVZDcxTTCFGF-2aCSFmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیIschemia - ایسکمیBrdU - بروموداکسی اوریدینbromodeoxyuridine - برومودسوویریدینTriphenyltetrazolium chloride - ترفتhenyltetrazolium chloridedoublecortin - دوچرخهAging - سالخوردگیcommon carotid arteries - شریانهای معمول کاروتیدGrowth factor - فاکتور رشدbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیNeuroprotection - محافظت نورونی یا محافظت از عصبBrain - مغزsubventricular zone - منطقه فرعیNeurogenesis - نوروژنز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Basic fibroblast growth factor (FGF-2) has been reported to protect against ischemic injury in the brains of young adult rodents. However, little is known about whether FGF-2 retains this capability in the aged ischemic brain. Since stroke in human is much more common in older people than among younger adults, to address this question is clinically important. In this study, aged (24-month-old) rats were treated with intracerebroventricular infusion of FGF-2 or vehicle for 3 days, beginning 48Â h before (pre-ischemia), 24Â h after (early post-ischemia), or 96Â h after (late post-ischemia) 60Â min of middle cerebral artery occlusion, and were killed 10 days after ischemia. Aged rats given FGF-2 pre-ischemia showed better symmetry of movement and forepaw outstretching, and reduced infarct volumes, compared to rats treated with vehicle, but no significant improvement was found in aged rats given FGF-2 after focal ischemia. In contrast, young adult (3-month-old) rats treated with FGF-2 for 3 days beginning 24Â h post-ischemia showed significant neurobehavioral improvement and better histological outcome. In addition, we also found that newborn neurons in the rostral subventricular zone (SVZ) were increased in aged rats treated with FGF-2 prior to ischemia. However, unlike in young adult ischemic rats, only a few of newly generated cells migrated into the damaged region in aged brain after focal ischemia. These findings point to differences in the response of aged versus young adult rats to FGF-2 in cerebral ischemia, and suggest that such differences need to be considered in the development of neuroprotective agents for stroke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1123, Issue 1, 6 December 2006, Pages 237-244
Journal: Brain Research - Volume 1123, Issue 1, 6 December 2006, Pages 237-244
نویسندگان
Seok Joon Won, Lin Xie, Sun Hee Kim, Huidong Tang, Yaoming Wang, XiaoOu Mao, Surita Banwait, Kunlin Jin,