کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4332112 | 1292887 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington’s disease Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington’s disease](/preview/png/4332112.png)
Huntington’s disease has an increase in the activated calpain, which is enhanced by the NMDA receptor activation. We investigated the neuroprotective effect of memantine in 3-nitropropionic acid (3NP)-induced striatal degeneration model. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered for five days with 3NP continuous infusion. In the memantine-treated group, the striatal lesion volume, the number of TUNEL+ cells, and Fluoro-Jade C+ degenerating neurons were all decreased. Memantine increased Bcl-xl and decreased Bax level. Memantine also exerted an inhibitory effect on the μ-calpain level and decreased the huntingtin proteolytic fragments. Those rats treated with memantine showed less degree of weight loss at 5 days. Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington’s disease.
Journal: Brain Research - Volume 1118, Issue 1, 6 November 2006, Pages 199–207