Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum

The present study examined the ability of antioxidant effects of angiotensin-converting enzyme (ACE) inhibitor, imidaprilat, on the synergistic effect of bisphenol A and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum. Bisphenol A clearly enhanced OH formation and DA efflux induced by MPP+. When imidaprilat was infused in bisphenol A and MPP+-treated rats, DA efflux and OH formation significantly decreased, as compared with that in the bisphenol A and MPP+ treated control. These results suggest that ACE inhibitors may protect against the synergistic effect of bisphenol A and MPP+-induced OH formation via suppressing DA efflux in the rat striatum.