کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4333658 1614473 2010 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system
چکیده انگلیسی

This review gives an overview of connexin expression in glial cells of the central nervous system, the different modes of connexin action, including gap junctional channels and hemichannels, as well as the available methodologies to measure their activity. We summarize the strengths and limitations of current pharmacological and genetic approaches to interfere with connexin channel functions. We outline new avenues not only to study specific mechanisms by which connexins exert these functions but also to selectively investigate well-defined coupling compartments among glial networks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Reviews - Volume 63, Issues 1–2, May 2010, Pages 160–176
نویسندگان
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