کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4335613 1295170 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis
چکیده انگلیسی
In this work, focal cerebral ischemia/reperfusion was induced by the model of middle cerebral artery occlusion. The dialysates of extracellular fluid in hypothalamus were obtained by using brain microdialysis technique. An efficient and sensitive chiral capillary electrophoresis with laser-induced fluorescence detection procedure was developed for the simultaneous determination of multiple amino acids neurotransmitter including Arg, Lys, Trp, GABA, l-Ser, Ala, Tau, Gly, Glu and Asp; catcholamine (dopamine) and neuromodulator (d-Ser and O-phosphoethanolamine) in microdialysate. Different parameters that influenced CE separation were optimized. The optimal method was used to investigate the dynamic changes of neurotransmitters and neuromodulators during cerebral ischemia/reperfusion. The results indicated that extracellular levels of multiple neurotransmitters and neuromodulators were elevated during cerebral ischemia/reperfusion. The dynamic changes and functional status of releasable neurotransmitters and neuromodulators during ischemia/reperfusion were discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 189, Issue 2, 15 June 2010, Pages 162-168
نویسندگان
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