کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4337052 | 1295239 | 2006 | 11 صفحه PDF | دانلود رایگان |
With the availability of sophisticated genetic techniques, the mouse is a valuable mammalian model to study the molecular and cellular basis of cognitive behaviors. However, the small size of mice makes it difficult for a systematic investigation of activity patterns of neural networks in vivo. Here we report the development and construction of a high-density ensemble recording array with up to 128-recording channels that can be formatted as single electrodes, stereotrodes, or tetrodes. This high-density recording array is capable of recording from hundreds of individual neurons simultaneously in the hippocampus of the freely behaving mice. This large-scale in vivo ensemble recording techniques, once coupled with mouse genetics, should be valuable to the study of complex relationship between the genes, neural network, and cognitive behaviors.
Journal: Journal of Neuroscience Methods - Volume 155, Issue 1, 15 July 2006, Pages 28–38