کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4337857 1614817 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The subthalamic activity and striatal monoamine are modulated by subthalamic stimulation
ترجمه فارسی عنوان
فعالیت سوپاتالامیک و مونوآمین استرییتال توسط تحریک سوپالاتالوم مدولاسیون می شوند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• We examined the effect of STN-DBS on the striatal monoamine and STN activities.
• The levels of 3–4-dihydroxyphenylacetic acid (DOPAC) were significantly decreased after the cessation of stimulation in PD model rats.
• STN beta power was elevated in normal rats and decreased in PD rats by STN-DBS.
• The STN beta power and the levels of DOPAC and 5-HT were positively correlated in PD model rats.

AimsNot all the mechanisms by which subthalamic nucleus deep brain stimulation (STN-DBS) alleviates parkinsonian symptoms have been clarified as yet. The levels of striatal monoamine and the subthalamic beta activity might contribute to its efficacy. However, their direct relationship is unclear. We aimed to examine the correlation between the striatal monoamine and the STN beta activity induced by STN-DBS.Experimental proceduresExperiments were performed under urethane anesthesia in normal (n = 4) and 6-hydroxydopamine hemi-lesioned Parkinson’s disease (PD) model rats (n = 5). STN-DBS was applied to the left STN, and local field potential (LFP) was recorded before and after STN-DBS. Striatal extracellular fluid was collected before, during, and after STN-DBS. Spectral analysis of STN-LFP was performed, and the levels of monoamine were measured.ResultsThe levels of 3–4-dihydroxyphenylacetic acid (DOPAC) were significantly decreased after the cessation of stimulation in PD model rats. The levels of none of the monoamines were significantly affected in normal rats. The STN beta power was significantly elevated after the cessation of stimulation in normal rats but was significantly decreased in PD model rats.The STN beta power and the levels of DOPAC and 5-HT was positively correlated in PD model rats, whereas the levels of dopamine and 5-HT showed positive correlation and the levels of DOPAC and Homovanillic acid (HVA) showed negative correlation in normal rats.ConclusionSTN-DBS could decrease the levels of DOPAC and the STN beta power in a PD model rat. The STN beta power and the levels of striatal monoamine might be differentially correlated between normal and PD model rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 259, 14 February 2014, Pages 43–52
نویسندگان
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