کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4337962 | 1614835 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-33 mediates formalin-induced inflammatory pain in mice
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کلمات کلیدی
SPSSRILST2IL-33USVsPBSERKextracellular-signal-regulated kinases - kineases regulated by extracellular-signal-regulatedMAPK - MAPKFormalin test - آزمون فرمالینUltrasound vocalizations - آوازآلات سونوگرافیInterleukin-33 - اینترلوکین 33Statistical Package for the Social Sciences - بسته های آماری برای علوم اجتماعیstandard error - خطای استانداردPain - دردCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیphosphate buffer solution - محلول بافر فسفاتSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیwild-type - نوع وحشیmitogen-activated protein kinases - کیناز پروتئین فعال Mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interleukin-33 mediates formalin-induced inflammatory pain in mice Interleukin-33 mediates formalin-induced inflammatory pain in mice](/preview/png/4337962.png)
چکیده انگلیسی
Interleukin-33 (IL-33), a member of the IL-1 family, has attracted growing interest since its discovery in 2003. IL-33 has been implicated in many diseases, including arthritis, asthma, allergies, and cardiovascular and infectious diseases. However, few studies have investigated its role in the transmission and modulation of pain. The present study was designed to explore the possible roles of IL-33 and its receptor, ST2, in formalin-induced inflammatory pain in mice. We found that both subcutaneous (s.c., 300Â ng) and intrathecal injection (i.t., 3Â ng) of recombinant IL-33 (rIL-33) increased paw lifting and licking time not only in normal mice but also in formalin models. Administration of ST2 antibody, which blocked the IL-33/ST2 signaling, alleviated the formalin-induced spontaneous pain behavior. Moreover, the ST2â/â mice showed significantly decreased pain behavior, as well as reduced ultrasonic vocalization induced by formalin, compared with the wild-type group. Additionally, ST2 antibody alleviated the potentiating effects of rIL-33 on pain behavior in the formalin mice, indicating that IL-33 plays a role in pain modulation through its ST2 receptor. These data suggest IL-33 and its ST2 receptor mediate formalin-induced inflammatory pain, and as a result this cytokine and its receptor may be new targets for the development of analgesics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 241, 25 June 2013, Pages 59-66
Journal: Neuroscience - Volume 241, 25 June 2013, Pages 59-66
نویسندگان
P. Han, J. Zhao, S.-B. Liu, C.-J. Yang, Y.-Q. Wang, G.-C. Wu, D.-M. Xu, W.-L. Mi,