کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338992 1614896 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intensity matters: brain, behaviour and the epigenome of prenatally stressed rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Intensity matters: brain, behaviour and the epigenome of prenatally stressed rats
چکیده انگلیسی

There is a general consensus that prenatal stress alters offspring brain development, however, the details are often inconsistent. Hypothesising that variation to the level of stress would produce different maternal experiences; this study was designed to examine offspring outcomes following a single prenatal stress paradigm at two different intensities. Pregnant Long Evans rats received mild, high, or no-stress from gestational days 12–16. Offspring underwent early behavioural testing and global methylation patterns were analysed from brain tissue of the frontal cortex and hippocampus. The two different prenatal stress intensities produced significantly different and often, opposite effects in the developing brain. Mild prenatal stress decreased brain weight in both males and females, whereas extreme stress increased female brain weight. Mild prenatal stress slowed development of sensorimotor abilities and decreased locomotion, whereas high prenatal stress also slowed development of sensorimotor learning but increased locomotion. Finally, mild prenatal stress increased global DNA methylation levels in the frontal cortex and hippocampus whereas high prenatal stress was associated with a dramatic decrease. The data from this study provide evidence to support a dose-dependent effect of prenatal stress on multiple aspects of brain development, potentially contributing to long-term outcomes.

▶Prenatal stress alters offspring behaviour. ▶Prenatal stress changes offspring DNA methylation patterns. ▶Prenatal stress produces sex-dependent changes in offspring brain. ▶Variations to prenatal stress intensity produce different outcomes in offspring.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 180, 28 April 2011, Pages 105–110
نویسندگان
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