Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice

▶Swedish amyloid precursor protein produces disturbances in retrosplenial cortex. ▶Cellular function disturbed with appearance of mutated APP-derived peptides. ▶Retrosplenial cortex disturbed prior to appearance of amyloid plaques. ▶Retrosplenial cortex function influenced by local and afferent pathology.