کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4339233 1614902 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of chronic pain on morphine-induced respiratory depression in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Effect of chronic pain on morphine-induced respiratory depression in mice
چکیده انگلیسی
▶Morphine (MOR)-induced respiratory depression (RD) was not observed in nerve-ligated mice. ▶This attenuation was reversed by 5-HT4a receptor antagonist. ▶5-HT4 receptor agonist, mosapride, antagonized the MOR-induced RD. ▶Expression of 5-HT4a receptor in brainstem was enhanced in nerve-ligated mice. ▶5-HT4a receptor up-regulation under chronic pain causes decrease in MOR-induced RD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 174, 3 February 2011, Pages 224-233
نویسندگان
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