کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340268 | 1295789 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurotensin inversely modulates maternal aggression
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کلمات کلیدی
ACTHMaternal defenseBNSTCeA - CEACentral amygdala - آمیگدالای مرکزیMaternal aggression - تجاوز مادرanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancelateral septum - سپتوم جانبیLactation - شیردهیFight - مبارزه کردنMice - موشneurotensin - نوروتنسینbed nucleus of the stria terminalis - هسته تخت ترمینال های استریmedial preoptic nucleus - هسته پیشوپتیک مدیاadrenocorticotropic hormone - هورمون adrenocorticotropicFlight - پروازcingulate cortex - کورتکس کانگولت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Neurotensin (NT) is a versatile neuropeptide involved in analgesia, hypothermia, and schizophrenia. Although NT is released from and acts upon brain regions involved in social behaviors, it has not been linked to a social behavior. We previously selected mice for high maternal aggression (maternal defense), an important social behavior that protects offspring, and found significantly lower NT expression in the CNS of highly protective females. Our current study directly tested NT's role in maternal defense. Intracerebroventricular (i.c.v.) injections of NT significantly impaired defense in terms of time aggressive and number of attacks at all doses tested (0.05, 0.1, 1.0, and 3.0 μg). Other maternal behaviors, including pup retrieval, were unaltered following NT injections (0.05 μg) relative to vehicle, suggesting specificity of NT action on defense. Further, i.c.v. injections of the NT receptor 1 (NT1) antagonist, SR 48692 (30 μg), significantly elevated maternal aggression in terms of time aggressive and attack number. To understand where NT may regulate aggression, we examined Fos following injection of either 0.1 μg NT or vehicle. Thirteen of 26 brain regions examined exhibited significant Fos increases with NT, including regions expressing NT1 and previously implicated in maternal aggression, such as lateral septum, bed nucleus of stria terminalis, paraventricular nucleus, and central amygdala. Together, our results indicate that NT inversely regulates maternal aggression and provide the first direct evidence that lowering of NT signaling can be a mechanism for maternal aggression. To our knowledge, this is the first study to directly link NT to a social behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 4, 18 February 2009, Pages 1215-1223
Journal: Neuroscience - Volume 158, Issue 4, 18 February 2009, Pages 1215-1223
نویسندگان
S.C. Gammie, K.L. D'Anna, H. Gerstein, S.A. Stevenson,