کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340350 | 1295790 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy
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کلمات کلیدی
Top1giant fibertopoisomerase 1Topoisomerase IBSSDLMEASMRTSDALSDCPTAEDECs - EC هاEpilepsy - بیماری صرعanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceseizure - تشنج least significant difference - حداقل تفاوت قابل توجهیanti-epileptic drug - داروهای ضد صرعSuppression - سرکوبelectroconvulsive shock - شوک الکتریکیHigh-frequency - فرکانس بالاcamptothecin - کامپتوتسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The Drosophila DNA topoisomerase type I mutant allele, top1JS is an effective general seizure-suppressor mutation, reverting seizure-sensitive phenotypes of several mutant strains in a genetic model of epilepsy. Seizure-suppression is caused by reduced transcription of the top1 (topoisomerase I gene) gene [Song J, Hu J, Tanouye MA. (2007) Seizure suppression by top1 mutations in Drosophila. J Neurosci 27(11):2927-2937]. Here, we examine the possibility that pharmaceutical inhibition of Top1 (topoisomerase I protein) enzymatic activity may also be effective at reducing seizure phenotypes. We investigate the effect of vertebrate Top1 inhibitor camptothecin (CPT) along with two related compounds, apigenin and kaempferol, when fed to seizure-sensitive mutant Drosophila. All three Top1 inhibitors were found to suppress phenotypes in these mutants. In particular, for drug treatments, the recovery time from seizure and paralysis is greatly reduced compared with untreated animals. Intriguingly we find that chronic drug treatments result in a small reduction in seizure sensitivity. Taken together, the results suggest that Top1 inhibitors may have the potential to be developed into effective anti-epileptic drugs, especially for brain tumor patients presenting with epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 156, Issue 3, 15 October 2008, Pages 722-728
Journal: Neuroscience - Volume 156, Issue 3, 15 October 2008, Pages 722-728
نویسندگان
J. Song, L. Parker, L. Hormozi, M.A. Tanouye,