کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340497 | 1295798 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40 Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40](/preview/png/4340497.png)
چکیده انگلیسی
The endopeptidase properties of β and γ splice forms of human MMEL were determined in HEK293T cells transduced with the human cDNAs for the two splice forms; this showed degradation of both Aβ42 and Aβ40 by hMMEL-β but not hMMEL-γ. hMMEL-β activity was found at the extracellular surface with no significant secreted activity. hMMEL-γ was not expressed at the extracellular surface. Finally, it was found that hMMEL cleaves Aβ near the α-secretase site (producing Aβ1-17â«Aβ1-16). These data establish hMMEL as a mediator of Aβ catabolism and raise the possibility of its involvement in the etiology of AD and as a target for intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 155, Issue 1, 31 July 2008, Pages 258-262
Journal: Neuroscience - Volume 155, Issue 1, 31 July 2008, Pages 258-262
نویسندگان
J.Y. Huang, A.M. Bruno, C.A. Patel, A.M. Huynh, K.D. Philibert, M.J. Glucksman, R.A. Marr,