کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340964 | 1295818 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endoplasmic reticulum stress response in dendrites of cultured primary neurons
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کلمات کلیدی
Eukaryotic initiation factor-2αtunicamycinNMDAN-methyl-d-aspartateUPRIRE1ATF6XBP1eIF2αPKR-like endoplasmic reticulum kinase - PKR-like reticulum kinase endoplasmicER stress - استرس استDendrite - دندریتendoplasmic reticulum - شبکه آندوپلاسمی activating transcription factor 6 - فعال کردن عامل رونویسی 6UTR یا untranslated regions - منطقه ترجمه نشدهuntranslated region - منطقه غیر ترجمهUnfolded protein response - پاسخ پروتئین آشکارX-box binding protein 1 - پروتئین اتصال X جعبه 1PERK - پرکProtein quality control - کنترل کیفیت پروتئین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Endoplasmic reticulum stress response in dendrites of cultured primary neurons Endoplasmic reticulum stress response in dendrites of cultured primary neurons](/preview/png/4340964.png)
چکیده انگلیسی
The endoplasmic reticulum (ER) is an organelle in which secretory and transmembrane proteins are folded or processed, and is susceptible to various stresses that provoke the accumulation of unfolded proteins in the ER lumen. Recently, ER stress has been reported to be linked to neuronal death in various neurodegenerative diseases. Neurons contain the ER not only in the soma, but also in the dendrites, thus presenting a different case to non-neuronal cells. The ER in the dendrites has potential functions in local protein synthesis and sorting of synthesized proteins to postsynaptic membranes. It raises the possibility that ER stress could occur locally in the dendrites. Here we showed that ER stress sensors, inositol-requiring 1 (IRE1), PKR-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) exist in the ER of both soma and dendrites in primary mouse neurons, and that under ER stress conditions, GRP78/BiP and phosphorylated eIF2α are induced. Furthermore, XBP1 mRNA was localized in the proximal dendrites where IRE1 was rapidly phosphorylated in response to ER stress. These results indicate that the ER in dendrites could respond to ER stress and retain the capacity of protein quality control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 146, Issue 1, 25 April 2007, Pages 1-8
Journal: Neuroscience - Volume 146, Issue 1, 25 April 2007, Pages 1-8
نویسندگان
T. Murakami, S.-I. Hino, A. Saito, K. Imaizumi,