کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341408 | 1295834 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon
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کلمات کلیدی
IODanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceintegrated optical density - تراکم نوری یکپارچهSerotonin - سروتونینPVN - مالیات بر ارزش افزودهhypothalamic–pituitary–adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالRats - موش صحراییHPA - میلی بار یا هکتوپاسکالHypothalamic paraventricular nucleus - هسته پروبیالیک هیپوتالامیکHypothalamus - هیپوتالاموسG proteins - پروتئین GProlactin - پرولاکتین Corticosterone - کورتیکوسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon](/preview/png/4341408.png)
چکیده انگلیسی
We previously reported that treatment and withdrawal from cocaine increases: (1) 5-HT2A receptor-mediated neuroendocrine responses, and (2) Gαq and Gα11 G-protein levels in the hypothalamic paraventricular nucleus (PVN) at 48 h post-treatment. This study investigates changes in the initial 24 h of withdrawal to discern whether 5-HT2A receptor supersensitivity is due to cocaine treatment or is induced during the withdrawal period. We report here increases in 5-HT2A receptor-mediated neuroendocrine responses only 12 or 24 h post-treatment, but not during the initial 4 h withdrawal period. Levels of membrane- or cytosol-associated Gαq or Gα11 proteins in PVN are not altered during the first 24 h of withdrawal. However, the density of 125I-(â)-1-(2,5 dimethoxy-4-iodophenyl)-2-amino-propane HCl (DOI)-labeled high-affinity 5-HT2A receptors in PVN increased 35% in rats withdrawn from cocaine for 24 h. These findings demonstrate that cocaine-induced increases in 5-HT2A receptor function in PVN represents a withdrawal-induced phenomena that: (1) is likely attributed to increased G-protein coupled/high-affinity conformational state of the 5-HT2A receptor, and (2) occurs in the absence of changes in the levels of associated G proteins during the first 24 h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 143, Issue 1, 17 November 2006, Pages 7-13
Journal: Neuroscience - Volume 143, Issue 1, 17 November 2006, Pages 7-13
نویسندگان
G.A. Carrasco, L.D. Van de Kar, N.R. Sullivan, M. Landry, F. Garcia, N.A. Muma, G. Battaglia,