کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341738 | 1295845 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: A preliminary study
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کلمات کلیدی
WCSTWAIS-RLIS1LCRHRSDLissencephalyPANSSANCOVAEndophenotype - آندوفنوتیپ intelligence quotient - بهره هوشیCovariance analysis - تجزیه کوواریانسWisconsin Card Sorting Test - تست مرتب سازی کارت ویسکانسینHamilton Rating Scale for Depression - مقیاس رتبه بندی همیلتون برای افسردگیpositive and negative syndrome scale - مقیاس مثبت و منفی سندرمNeuronal migration - مهاجرت نورونpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازPlatelet activating factor receptor - گیرنده فاکتور فعال کننده پلاکت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Both neural development and prefrontal cortex function are known to be abnormal in schizophrenia and bipolar disorder. In order to test the hypothesis that these features may be related with genes that regulate neuronal migration, we analyzed two genomic regions: the lissencephaly critical region (chromosome 17p) encompassing the LIS1 gene and which is involved in human lissencephaly; and the genes related to the platelet-activating-factor, functionally related to LIS1, in 52 schizophrenic patients, 36 bipolar I patients and 65 normal control subjects. In addition, all patients and the 25 control subjects completed a neuropsychological battery. Thirteen (14.8%) patients showed genetic variations in either two markers related with lissencephaly or in the platelet-activating-factor receptor gene. These patients performed significantly worse in the Wisconsin Card Sorting Test-Perseverative Errors in comparison with patients with no lissencephaly critical region/platelet-activating-factor receptor variations. The presence of lissencephaly critical region/platelet-activating-factor receptor variations was parametrically related to perseverative errors, and this accounted for 17% of the variance (P=0.0001). Finally, logistic regression showed that poor Wisconsin Card Sorting Test-Perseverative Errors performance was the only predictor of belonging to the positive lissencephaly critical region/platelet-activating-factor receptor group. These preliminary findings suggest that the variations in genes involved in neuronal migration predict the severity of the prefrontal cognitive deficits in both disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 139, Issue 4, 2006, Pages 1289-1300
Journal: Neuroscience - Volume 139, Issue 4, 2006, Pages 1289-1300
نویسندگان
R. Tabarés-Seisdedos, T. Escámez, J.A. MartÃnez-Giménez, V. Balanzá, J. Salazar, G. Selva, C. Rubio, E. Vieta, E. Geijó-Barrientos, A. MartÃnez-Arán, O. Reiner, S. MartÃnez,