RIT2 rs12456492 polymorphism and the risk of Parkinson’s disease: A meta-analysis

• We performed a meta-analysis to assess the rs12456492(A/G) polymorphism of RIT2 in PD.
• The rs12456492(A/G) polymorphism was associated with the risk of PD in all genetic models.
• The G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of PD.

Many published case-control studies have investigated the association between rs12456492(A/G) variant in RIT2 gene and the risk of Parkinson's disease(PD); however, an ambiguous conclusion remains elusive. Our aim was to evaluate the association of RIT2 rs12456492(A/G) polymorphism with the risk of PD. We searched the Pubmed, Science Direct, EMBASE and EBSCO databases up to May 2015 for related studies. A total of 5 studies with 2541 PD cases and 2531 controls were included in the meta-analysis based on the strict inclusion and exclusion criteria. STATA 12.0 statistics software was used to calculate available data from each study. The pooled odds ratios (OR) and 95% confidence interval (CI) were calculated to assess the genetic association between RIT2 rs12456492 polymorphism and the risk of PD. There is a significant association between rs12456492 and PD (Gvs.A:OR = 1.024, 95%CI:1.112–1.303, P = 0.001; GGvs.AA:OR = 1.486, 95%CI:1.259–1.755, P = 0.001; GAvs.AA:OR = 1.217, 95%CI:1.071–1.383, P = 0.003; GG + GAvs.AA:OR = 1.290, 95%CI:1.143–1.455, P = 0.001; GGvs.GA + AA:OR = 1.262, 95%CI:1.097–1.451, P = 0.001). The data of our meta-analysis indicates that the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of PD.