کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343437 1615100 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular matrix protein reelin regulate dendritic spine density through CaMKIIβ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Extracellular matrix protein reelin regulate dendritic spine density through CaMKIIβ
چکیده انگلیسی


• Reelin increased dendritic spine density by altering the puncta number of synaptophysin and PSD-95.
• Reelin increased the levels of CaMKIIβ in primary hippocampal neurons.
• CaMKIIβ shRNA transfected primary hippocampal neurons prevented the effects of Reelin on dendritic spine density.

Reelin, an extracellular matrix protein, plays an important role in brain development as well as synaptic plasticity. Interestingly, several recent studies have found that Reelin is important for dendritic spine formation in vitro and in vivo. However, the molecular mechanism by which Reelin regulates the dendritic spine density has not been studied well yet. In this study, we found that exogenous Reelin treatment was significantly increased the dendritic spine density in the primary hippocampal neurons. In addition, Reelin was increased the puncta numbers of synaptophysin and PSD-95. Moreover, we found that Reelin modulated the levels of CaMKIIβ, and CaMKIIβ siRNA prevented Reelin's effect on the dendritic spine density. Overall, our results are the first to demonstrate that CaMKIIβ might be required to enable Reelin to alter the dendritic spine density.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 599, 10 July 2015, Pages 97–101
نویسندگان
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