کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343442 1615100 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats
ترجمه فارسی عنوان
ایزوالین موجب کاهش فعالیت اپیلتیمتریک کلی در هیپوکامپ و قوزکهای حسی اولیه و رفتار تشنج در موشهای صحرایی شده با پروتئین پیلوکارپین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Isovaline attenuated hippocampal epileptiform activity in pilocarpine treated rats.
• Isovaline attenuated epileptiform activity in S1 cortex in pilocarpine treated rats.
• Isovaline attenuated behavioral generalized seizures in pilocarpine treated rats.

Anti-seizure drugs are the most commonly employed treatment option for epilepsy and these generally provide effective management of seizures. However, 30% of patients with epilepsy are not adequately treated with anti-seizure medications and are considered intractable. Recently we reported that isovaline, a unique amino acid, could attenuate seizure like events (SLEs) in two in vitro hippocampal seizure models by selectively increasing the activity of interneurons, but not pyramidal neurons. Isovaline also attenuated hippocampal epileptiform activity and behavioral seizures in vivo in rats administered 4 aminopyridine (4AP). Here, we investigate whether isovaline is efficacious in attenuating secondarily generalized epileptiform activity and behavioral seizures in rats administered pilocarpine. We found that 150 mg/kg isovaline administered intravenously abolished pilocarpine-induced epileptiform activity in the primary sensory cortex and hippocampus and attenuated generalized forebrain behavioral seizures. We are the first to demonstrate that isovaline may be a plausible anti-seizure drug for secondarily generalized seizures and this could potentially lead to the development of a novel class of anti-seizure drugs focused around the unique mechanism(s) of isovaline.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 599, 10 July 2015, Pages 125–128
نویسندگان
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