کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343525 1615106 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spinal vasopressin alleviates formalin-induced nociception by enhancing GABAA receptor function in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Spinal vasopressin alleviates formalin-induced nociception by enhancing GABAA receptor function in mice
چکیده انگلیسی


• We have found that spinal AVP reduced formalin-induced spontaneous nociception.
• Spinal AVP analgesia were mediated by V1A receptors.
• Enhancing GABAergic function may be involved in the mechanism underlying spinal AVP analgesia.

Arginine vasopressin (AVP) plays a regulatory role in nociception. Intrathecal administration of AVP displays an antinociceptive effect. However, little is understood about the mechanism underlying spinal AVP analgesia. Here, we have found that spinal AVP dose dependently reduced the second, but not first, phase of formalin-induced spontaneous nociception in mice. The AVP analgesia was completely blocked by intrathecal injected SR 49059, a vasopressin-1A (V1A) receptor antagonist. However, spinal AVP failed to exert its antinociceptive effect on the second phase formalin-induced spontaneous nociception in V1A receptor knock-out (V1A-/-) mice. The AVP analgesia was also reversed by bicuculline, a GABAA receptor antagonist. Moreover, AVP potentiated GABA-activated currents in dorsal root ganglion neurons from wild-type littermates, but not from V1A-/- mice. Our results may reveal a novel spinal mechanism of AVP analgesia by enhancing the GABAA receptor function in the spinal cord through V1A receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 593, 23 April 2015, Pages 61–65
نویسندگان
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