کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343857 1615138 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ethanol attenuates sensory stimulus-evoked responses in cerebellar granule cells via activation of GABAA receptors in vivo in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Ethanol attenuates sensory stimulus-evoked responses in cerebellar granule cells via activation of GABAA receptors in vivo in mice
چکیده انگلیسی


• Whisker pad stimulation evokes stimulus-on and stimulus-off response in granule cells of cerebellar cortex Crus II.
• Perfusion of ethanol inhibits the sensory stimulation-evoked response in cerebellar granule cells.
• Blockade of GABAA receptors activity abolishes the ethanol-induced inhibition of the sensory responses of granule cells.

Acute alcohol intoxication affects cerebellar motor regulation possibly by altering the transfer and integration of external information in cerebellar cortical neurons, resulting in a dysfunction of cerebellar motor regulation or a cerebellar atexia. However, the synaptic mechanisms of ethanol induced impairments of sensory information processing in cerebellar cortical neurons are not fully understand. In the present study, we used electrophysiological and pharmacological methods to study the effects of ethanol on the sensory stimulation-evoked responses in cerebellar granule cells (GCs) in vivo in urethane anesthetized mice. Air-puff stimulation of the ipsilateral whisker-pad evoked stimulus-on (P1) and stimulus-off responses (P2) in GCs of cerebellar Crus II. Cerebellar surface perfusion of ethanol did not alter the onset latency of the sensory stimulation-evoked responses, but reversible reduced the amplitude of P1 and P2. The ethanol-induced reduction of the GCs sensory responses was concentration-dependent. In the presence of ethanol, the mean half-width, area under curve, rise Tau and decay Tau of P1 were significantly decreased. Blockade of gamma-aminobutyric acid type A (GABAA) receptors activity induced an increase in amplitude of P1, and abolished the ethanol induced inhibition of the GCs sensory responses. These results indicate that ethanol inhibits the tactile evoked responses in cerebellar GCs through enhancement of GABAA receptors activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 561, 21 February 2014, Pages 107–111
نویسندگان
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