کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343921 1615143 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basal blood corticosterone level is correlated with susceptibility to chronic restraint stress in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Basal blood corticosterone level is correlated with susceptibility to chronic restraint stress in mice
چکیده انگلیسی


• Repeated restraint stress gives rise to susceptible and resilient responses.
• Different stress susceptibility is associated with different anxiety behavior.
• Basal level of corticosterone is strongly correlated with stress susceptibility.

Corticosterone is released in response to stress and manifests as various bodily stress responses in rodents. While corticosterone reflects acute adaptive responses, how the basal steady-state corticosterone level relates to the subsequent stress response is largely unknown. Here, we investigated how basal corticosterone levels can affect the susceptibility to chronic restraint stress in mice. We designed a longitudinal experiment, enabling us to compare the basal corticosterone level and the subsequent response to repeated restraint stress within the same animal. We found that the mice had differential changes in plasma corticosterone levels, which either increased or decreased, with exposure to chronic stress. These differential changes reflected the differential stress susceptibility of the mice, as evaluated by changes in body weight. The extent of the changes in corticosterone level during chronic stress exposure was predicted by the basal corticosterone level. In addition, the behavioral consequence of chronic stress was also correlated with the basal corticosterone level prior to chronic stress experience. These data reveal that the basal steady-state corticosterone level is a predictor of stress susceptibility or resilience to subsequent stress exposures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 555, 25 October 2013, Pages 137–142
نویسندگان
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