Time-dependent repression of mPer2 expression in the suprachiasmatic nucleus by inhalation anesthesia with sevoflurane

► Sevoflurane anesthesia shows a time-dependent repressive effect on mPer2 expression in the SCN. ► The light conditions modify the anesthetic effects on mPer2 expression. ► The anesthesia also affects the rest/activity rhythm of mouse behavior but without observable time-dependence.