The delivery of tyrosine hydroxylase accelerates the neurorestoration of Macaca Rhesus model of Parkinson's disease provided by Neurturin

► We applied Neurturin and TH to provide an enhanced gene therapy to Monkey model of PD. ► We constructed a bicistronic adenovirus expressing NTN and TH simultaneously. ► Bicistronic treated group displayed instant and faster behavior recovery. ► The delivery of TH could accelerate the behavior recovery mediated by NTN.