Effects of valproic acid on the expression of trophic factors in human bone marrow mesenchymal stromal cells

► Various trophic factors are significantly increased in valproate-treated hBM-MSCs (VPA-MSCs). ► VPA-MSCs showed increased protective effects against oxidative stress. ► VPA-MSCs showed increased migratory ability. ► It suggests that VPA may be a candidate for the improvement of stem cells as trophic mediator.