Passive immunization with tenascin-R (TN-R) polyclonal antibody promotes axonal regeneration and functional recovery after spinal cord injury in rats

► TN-R is an important axonal regeneration inhibitor after SCI. ► We develop TN-R polyclonal antibody which promotes neurite outgrowth in vitro. ► TN-R antibody improves functional recovery in a rat model of SCI. ► Passive immunotherapy with TN-R antagonist is a promising repair strategy after SCI.