Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats

► Spinal MCP-1 and its receptor CCR2 increase in cancer-induced bone pain rats. ► Intrathecal anti-MCP-1 antibody attenuate cancer-induced mechanical allodynia. ► Intrathecal recombinant MCP-1 induced mechanical allodynia in naïve rats.