White matter alterations in the corpus callosum of adolescents with first-admission schizophrenia

► We examined adolescents with first-admission schizophrenia and healthy controls. ► We used diffusion tensor imaging to examine the corpus callosum. ► We found fractional anisotropy alterations in the genu and the body. ► The corpus callosum seems to play a central role in early stages of schizophrenia.