کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4344610 1296668 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin 1 receptor contributes to methamphetamine- and sleep deprivation-induced hypersomnolence
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Interleukin 1 receptor contributes to methamphetamine- and sleep deprivation-induced hypersomnolence
چکیده انگلیسی

Methamphetamine-induced wakefulness is dependent on monoamine transporter blockade. Subsequent to methamphetamine-induced wakefulness, the amount of time spent asleep and the depth of sleep are increased relative to baseline sleep. The mechanisms that drive methamphetamine-induced hypersomnolence are not fully understood. We recently observed that methamphetamine exposure elevates the expression of the sleep-promoting cytokine, interleukin-1β in CD11b-positive monocytes within the brain. Here, we sought to determine whether activation of the interleukin 1 receptor (IL1R) drives the increase in the depth and amount of sleep that occurs subsequent to methamphetamine-induced wakefulness. IL1R-deficient mice and wild type control mice were subjected to systemic methamphetamine (1 and 2 mg/kg) and saline treatments. The wake-promoting effect of methamphetamine was modestly potentiated by IL1R-deficiency. Additionally, the increase in time spent in NREMS subsequent to methamphetamine-induced wakefulness in wild type mice was abolished in IL1R-deficient mice. The increase in time spent asleep after 3 h of behaviorally enforced wakefulness was also abolished in IL1R-deficient mice. Increases in EEG slow wave activity triggered by methamphetamine and sleep deprivation were of equal magnitude in IL1R-deficient and wild type mice. These data demonstrate that IL1R activation contributes to hypersomnolence that occurs after sleep loss, whether that sleep loss is triggered pharmacologically by methamphetamine or through behavioral sleep deprivation.


► Methamphetamine induces waking in interleukin 1 receptor-deficient (IL1R KO) mice.
► Methamphetamine-induced hypersomnolence is attenuated in IL1R KO mice.
► Sleep deprivation-induced hypersomnolence is also attenuated in IL1R KO mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 513, Issue 2, 4 April 2012, Pages 209–213
نویسندگان
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