کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4344706 1296675 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders
چکیده انگلیسی

N-Methyl-d-aspartate (NMDA) receptor, one of the glutamate receptors, has a role in the regulation of synaptic activity. It functions as an ion channel in the central nervous system and its inappropriate activation has been implicated in several neurological conditions. To test the association between candidate genes related with NMDA receptors and autism spectrum disorders (ASDs), we examined single nucleotide polymorphisms (SNPs) for GRIN2A and GRIN2B by using the family-based association test (FBAT) in 151 Korean trios. There was a statistically significant associations between ASDs and haplotypes in GRIN2B (bi-allelic mode additive model P-value = 0.003; FDR P-value = 0.012). This study supports a possible role of GRIN2B as a candidate gene for the etiology of ASDs.


► The associations between SNPs in GRIN2A/GRIN2B gene and Korean ASD were examined.
► There are associations between ASDs and haplotypes of GRIN2B in FBAT.
► GRIN2B may have a possible role in the etiology of ASDs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 512, Issue 2, 23 March 2012, Pages 89–93
نویسندگان
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