Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells

► We investigate the effect of costunolide dopamine (DA)-induced apoptosis in vitro. ► Costunolide regulates DA-metabolism associated ASYN, Nurr1, DAT, and VMAT2 genes. ► These four key proteins are involved in Parkinson's disease pathogenesis. ► Costunolide is suggested as a therapeutic candidate for Parkinson's disease.