Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy

► We test the function of the PGE2 receptors in neonatal hypoxia ischemia (HIE). ► All four PGE2 receptors are expressed after neonatal hypoxia ischemia. ► Inhibition of the EP1 receptor is cerebroprotective. ► Activation of the EP2-4 receptors is cerebroprotective. ► Supports future study of these G-protein coupled receptors in HIE.