کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4345133 | 1296706 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Inhibitory effects of calcitonin gene-related peptide on long-term potentiation induced in hippocampal slices of rats Inhibitory effects of calcitonin gene-related peptide on long-term potentiation induced in hippocampal slices of rats](/preview/png/4345133.png)
It is well known that hippocampus plays important roles in learning and memory. Both calcitonin gene-related peptide (CGRP) and CGRP receptors are found in hippocampus. In the present study we explored the influence of CGRP on long term potentiation (LTP) in hippocampal Schaffer collateral-CA1. Our results demonstrated that CGRP inhibited the LTP induced by high frequency stimulation (HFS) in hippocampal CA1 neurons in rat brain slices. The inhibitory effect was blocked by CGRP receptor-1 antagonist CGRP 8-37. The results indicate that both CGRP and CGRP receptor 1 are involved in the modulation process of LTP in hippocampus of rats.
► CGRP inhibits the HFS-induced LTP in hippocampal CA1 slices.
► The CGRP-induced inhibition on LTP is blocked by CGRP antagonist CGRP 8-37.
► CGRP and CGRP receptor 1 are involved in learning and memory in hippocampus.
Journal: Neuroscience Letters - Volume 494, Issue 1, 20 April 2011, Pages 10–13