Ras signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/− mice

► Blocking Ras activity does not reduce excitability in Nf1+/− sensory neurons. ► NGF-induced increases in excitability are Ras-dependent. ► Ras-GTP initiates reversible and irreversible changes in sensory neuron excitability.