Up-regulation of dendritic Kv4.2 mRNA by activation of the NMDA receptor

► The levels of Kv4.2 mRNA in the dendrites are increased by neuronal activity. ► The increase is mediated by transcription- and translation-independent mechanisms. ► The effect of high potassium is mimicked by glutamate treatment. ► The increase is mediated by synaptic NMDA receptor- and Ca2+-dependent mechanisms.